| 2021-09-03 07:38:41September 3, 2021 | Football: Green Street Academy vs. Phelps | 66 - 0 | Phelps High School |
| 2021-09-03 09:25:04September 3, 2021 | Football: Roosevelt @ Riverdale Baptist | 40 - 20 | Riverdale Baptist School |
| 2021-09-03 15:00:41September 3, 2021 | Football: St. John's Prospect Hall @ Sidwell Friends | 8 - 45 | Sidwell Friends School |
| 2021-09-03 15:30:18September 3, 2021 | Football: O'Connell @ St. Stephen's & St. Agnes | 0 - 12 | St. Stephen's & St. Agnes School |
| 2021-09-03 16:00:16September 3, 2021 | Football: Flint Hill @ St. Christopher's | 0 - 55 | St. Christopher's School |
| 2021-09-03 16:15:48September 3, 2021 | Football: Maret @ Bell Multicultural School | 14 - 22 | Bell Multicultural High School |
| 2021-09-03 18:00:30September 3, 2021 | Football: Georgetown Prep @ Pallotti | 14 - 28 | Pallotti High School |
| 2021-09-03 18:00:47September 3, 2021 | Football: Anacostia @ Allegany | 14 - 6 | Anacostia High School |
| 2021-09-03 18:00:50September 3, 2021 | Football: McKinley Tech @ Dunbar | 0 - 60 | Dunbar High School |
| 2021-09-03 18:08:08September 3, 2021 | Football: Paul VI @ St. John Paul the Great | 26 - 14 | Saint John Paul the Great Catholic High School |
| 2021-09-03 19:00:00September 3, 2021 | Football: DeMatha @ Imhotep Charter (PA) | 10 - 14 | Imhotep Institute Charter High School |
| 2021-09-03 19:00:05September 3, 2021 | Football: Surratsville @ Ballou | 14 - 24 | Ballou High School |
| 2021-09-03 19:00:16September 3, 2021 | Football: Catholic (LA) @ Good Counsel | 38 - 10 | Good Counsel High School |
| 2021-09-03 19:00:18September 3, 2021 | Football: St. James School @ Clear Spring High School | 60 - 12 | Clear Spring High School |
| 2021-09-03 19:00:40September 3, 2021 | Football: Gonzaga @ McDonogh | 23 - 7 | McDonogh School |
| 2021-09-03 19:00:52September 3, 2021 | Football: Wilson @ Yorktown | 16 - 43 | Yorktown High School |
| 2021-09-04 12:12:56September 4, 2021 | Football: Northeast @ Landon | 6 - 36 | Landon School |
| 2021-09-04 13:00:13September 4, 2021 | Football: McNamara @ Trinity Episcopal | 27 - 13 | Trinity Episcopal School |
| 2021-09-04 13:00:25September 4, 2021 | Football: St. Albans @ Bishop Ireton | 33 - 15 | Bishop Ireton High School |
| 2021-09-04 13:00:30September 4, 2021 | Football: Norfolk Academy @ Potomac School | 7 - 0 | Potomac School |
| 2021-09-04 14:00:29September 4, 2021 | Football: Butler (NC) @ St. John's | 0 - 33 | St. John's College High School |
| 2021-09-04 14:00:54September 4, 2021 | Football: Bullis @ Carroll | 6 - 38 | Archbishop Carroll High School |
| 2021-09-04 18:30:11September 4, 2021 | Football: St. Mary's Ryken @ St. Joseph's Prep (PA) | 0 - 40 | St. Joseph's Preparatory School |
