| 2021-08-28 14:00:29August 28, 2021 | Football: Friendship Collegiate @ Gonzaga | 0 - 37 | Gonzaga College High School |
| 2021-09-03 19:00:40September 3, 2021 | Football: Gonzaga @ McDonogh | 23 - 7 | McDonogh School |
| 2021-09-10 18:30:59September 10, 2021 | Football: St. Mary's Ryken @ Gonzaga | 0 - 19 | Gonzaga College High School |
| 2021-09-17 19:00:26September 17, 2021 | Football: Gonzaga @ St. Joseph Prep (PA) | 3 - 38 | St. Joseph's Preparatory School |
| 2021-09-24 19:00:41September 24, 2021 | Football: Gonzaga @ Archbishop Spalding | 13 - 20 | Archbishop Spalding High School |
| 2021-10-01 19:00:26October 1, 2021 | Football: Avalon @ Gonzaga | 34 - 49 | Gonzaga College High School |
| 2021-10-08 19:00:22October 8, 2021 | Football: Gonzaga @ DeMatha | 6 - 30 | DeMatha High School |
| 2021-10-16 13:00:49October 16, 2021 | Football: Good Counsel @ Gonzaga | 17 - 0 | Gonzaga College High School |
| 2021-10-30 12:00:32October 30, 2021 | Football: Gonzaga @ McNamara | 14 - 0 | Bishop McNamara High School |
| 2021-11-05 18:30:32November 5, 2021 | Football: St. John's @ Gonzaga | 20 - 17 | Gonzaga College High School |
| 2021-11-14 13:00:00November 14, 2021 | Football: WCAC Playoffs: Gonzaga vs. St. John's | 0 - 28 | St. John's College High School |
